Phase II PS-OC

2016 grants

Johns Hopkins Institute for NanoBioTechnology Receives National Cancer Institute Grant to Support Physical Sciences-Oncology Center

Johns Hopkins Institute for NanoBioTechnology (INBT) has been awarded a five-year, $9 million grant from the National Cancer Institute (NCI) to support a Physical Sciences-Oncology Center (PS-OC). Johns Hopkins University is one of 10 PS-OCs selected to participate in the NCI Physical Sciences-Oncology Network (PS-ON).

The PS-ON supports innovative ideas that blend perspectives and approaches from the physical sciences, engineering, and cancer research, with the goal of improving our current understanding of cancer biology and oncology. Transdisciplinary teams in each PS-OC collaborate on integrated projects investigating complex and challenging questions in cancer research through the incorporation of physical sciences perspectives and multi-scale modeling. The teams employ physical sciences approaches and perspectives to study intratumor heterogeneity of genomic, proteomic, and phenotypic profiles, tumor-immune interactions, evolutionary dynamics of treatment response, tumor microenvironment, tumor cell metabolism, and cancer metastasis. Additionally, each PS-OC supports an education and outreach program to promote training and career development at the intersection of physical sciences and oncology and to disseminate research advances to the broader cancer research and physical sciences communities.


END Phase I PS-OC 2009-2015

2013 grants

  • “Establishing an in vitro ductal model for breast cancer” – David Gracias, Lewis Romer & Saraswati Sukumar
  •  “Measuring cellular water permeation dynamics with infrared imaging” – Sean Sun & Konstantinos Konstantopoulos
  • “Characterization of epigenetic heterogeneity in cancer” – Winston Timp & Kasper Hansen
  • “CNS drug delivery facilitated by novel membrane translocating peptides” – Kalina Hristova & Dwight Bergles
  • “Epigenetic inheritance in adult stem cells and cancer cells” – Xin Chen & Jie Xiao
  •  “Nanobiosensors for non-invasive visualization of the AKT signaling pathways in cancer” – Assaf Gilad & Michael McMahon

2012 grants

Status: rewarded.

2011 grants

Status: rewarded.

2010 grants

Status: rewarded.

Unraveling the roles of obscure obscurins in cancer development
– Lead Investigator: Aikaterini Kontrogianni-Konstantopoulos, Ph.D. (University of Maryland Baltimore)
– Co-Investigator: Konstantinos Konstantopoulos, Ph.D.

Microfluidics for Studies of Angiogenesis in Oxygen Gradients
– Lead Investigator: German Drazer, Ph.D.
– Co-Investigator: Sharon Gerecht, Ph.D.

Microribonucleic acids in the physical properties of cancer cells
– Lead Investigator: Yiider Tseng, Ph.D. (University of Florida)
– Co-Investigator: Konstantinos Konstantopoulos, Ph.D.

Role of dc electric fields in the motility of cancer cells
– Lead Investigator: Peter Searson, Ph.D.
– Co-Investigator: Denis Wirtz, Ph.D.